When the Aqua Teens go to Panama City for a vacation, Meatwad leaves Carl to babysit Dewey, Vanessa, and Boxy Brown. At first, Carl thinks not having the Aqua Teens around is great, but soon realizes that hanging around the neighborhood by himself is a real drag.Meanwhile, in Panama City, Meatwad tries to start a comedy act, Frylock tries to get some action, and Shake loafs around the hotel room.