Rushing to attend the birth of his child, a fuel tanker driver crashes into Holby General's Acute Assessment Unit. Immediate evacuation of the hospital has begun as the tanker leaks petrol into the hospital basement. The driver's wife delivers a mixed-race son who is identifiably the result of an extra-marital affair. The driver dies unaware of his wife's infidelity, and as the baby begins to experience breathing difficulties, his mother rejects him. Connie Beauchamp and Alistair Taylor are forced to complete open heart surgery on a child as the evacuation continues, held hostage by the child's father. Paramedic Luke Warren fails to spot the deadly symptoms of a student with Lassa fever, and receptionist Bex Reynolds is lured up to Nightingale Wing pharmacy by a fake pharmaceutical representative. As the generator is switched off in the basement, the petrol explodes and the Nightingale building bursts into flames, trapping numerous staff members inside.